【摘要】MicroRNAs(miRNAs)是小RNA由植物,动物,病毒和至少一个单细胞的有机体表示了的-22nt,绿水藻,Chlamydomonasreinhardtii[1]。MostmiRNAs被RNAII作为主要miRNAs(pri-miRNAs)抄录,尽管一些被RNAIII抄录。在动物,pri-miR-NAs被二连续endonucleolytic劈开变换成成熟miRNAs[2]。pri-miRNA被Drosha首先切成原子核,aribonucleaseIII(RNaseIII)酶,与它的双stranded扮演RNA有约束力的领域(dsRBD)蛋白质搭挡,在脊椎动物的叫的DGCR8和在无
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