【摘要】ArachidonicacidcytochromeP-450(CYP)hydroxylase4Aisoforms,including4A1,4A2,4A3and4A8intheratkidney,catalyzearachidonicacidtoproduce19/20-Hydroxyeicosatetraenoicacids(20-HETE),abiologicallyactivemetabolite,whichplaysanimportantroleintheregulationofbloodpressure.However,controversialresultshavebeen
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